Poloxamerisavailbableinseveraltypes,confromingtothefollowingrequirements.ThiskindofsurfactantswerefirstlydevelopedbyAmerica.Theyhavealmostnotoxicity,littleirritationontheskinandthemucosa.Theyarewidelyusedasemulsifier,solubilizingagent,hydrophilicsubstrateofointmentsandsuppositories,artificialblood,artificialtearandartificialskinetc. executedstandard: tradename F-68 F-88 F-98 F-108 F-127 unsaturation(meq/g) 0.065 0.035 0.065 0.035 0.065 0.035 0.065 0.035 0.065 0.035 averagemolecularweight 8350 1000 10800 1000 13500 1000 15500 1000 11500 1000 meltpoint( c) 50 2 55 5 56 2 57 2 56 2 cloudpoint( c,1%aqueoussolution) 100 100 100 100 100 heavymetalcontent(ppm,max) 20 20 20 20 20 arsenicsalt(%,max) 0.0002 0.0002 0.0002 0.0002 0.0002 PH 5-7.5 5-7.5 5-7.5 5-7.5 5-7.5 application F-127gelcanbeusedascarrierforcontrollingandreleasinganticancerdrug,formedicineappliedtorectumfordiminishinginflammationandrelievingpain.Itisalsousedfortheconrolledandreleasedmedicinewhichisappliedtothemucosaofnavityandvagina. F-68canbeusedasdefoamingagentforbloodcirculationintheartificialheart-lungmachineinordertopreventtheairfromenteringthebloodofthepatient,decreasetheformationof foamandincreaseoxygenation.Intheproductionofsoliddispersionmedicine,asacarrier,itcangreatlyenhancetherateofdissolvingoutandbiologicalutilizationofthemedicine.Itisarelativelyidealquick-actingcarrierforsoliddispersion.