Metformin Hydrochloride
Product Name: Metformin Hydrochloride
Synonyms: Metformin HCL;3-(diaminomethylidene)-1,1-dimethylguanidine hydrochloride (1:1); 1,1-dimethylbiguanide hydrochloride
CAS: 1115-70-4
Assay: 99%
Packing: 25kg/drum
MF: C4H12ClN5
MW: 165.62
EINECS: 214-230-6
Appearance: White crystals or white crystalline powder

Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform

Metformin is a biguanide oral hypoglycemic agents, also known as metformin hydrochloride, Glucophage, metformin, phenformin hypoglycemic effect than to be weak, the main role is to reduce the A cell glucagon secretion, promote the conversion of glucose to glycogen, which can not stimulate islet beta cell insulin secretion.

The mechanism of hypoglycemic:

1 increase the sensitivity in the peripheral tissues to insulin, increased insulin mediated glucose utilization.

2, increase the use of non insulin dependent tissue glucose, such as brain, blood cells, renal medulla, gut, skin etc..

3 inhibition of hepatic gluconeogenesis, reduce hepatic glucose output.

4 inhibition of intestinal wall cells and glucose uptake.

5 inhibition of cholesterol biosynthesis and storage, reduce blood triglyceride, total cholesterol levels.

Clinical on metformin hydrochloride is mainly used for the treatment of simple diet control is not satisfactory in patients with type Ⅱ diabetes and obesity, especially with hyperinsulinemia, with this medicine not only has hypoglycemic effect, may also reduce weight and hyperinsulinemia effect. For some sulfonylurea efficacy in patients with poor work, such as sulfonylurea,

Intestinal glucosidase inhibitors or thiazolidine two ketones antidiabetic drugs, better effect than single use respectively. Can also be used in insulin treated patients, in order to reduce the amount of insulin.
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