10% LMD in 5% Dextrose Injection(Dextran 40 in Dextrose Injection, USP)10% LMD in 0.9% Sodium Chloride Injection(Dextran 40 in Sodium Chloride Injection, USP)Low Molecular Weight Dextran forIntravenous AdministrationFlexible Plastic ContainerRx onlyDEscriptIonLMD (dextran 40) is a sterile, nonpyrogenic preparation of low molecular weightdextran (average mol.wt. 40,000) in 5% Dextrose Injection or 0.9%SodiumChlorideInjection. It is administered byintravenous infusion.Also described as low viscous or low viscosity dextran, dextran 40 is prepared by acid hydrolysis anddifferential fractionation of a crudemacromolecular polysaccharide produced from the fermentation ofsucrose by the bacterium, Leuconostoc mesenteroides(strain B-512). The crude material is composed oflinked glucose units. In the fraction represented bydextran 40, 80% of the molecules have a molecularweight ranging from 10,000 to 90,000 (average approximately 40,000) when measured by a lightscattering method. More than 90% of the linkages are of the 1,6 alpha glucosidic, straight chain type.Each 100 mL of 10% LMD (dextran 40) in 5% Dextrose Injection contains 10 g dextran 40 and 5 gdextrose hydrous in water for injection. Total osmolar concentration is 255 mOsmol/liter (calc.); pH is 4.4(3.0 to 7.0).Each 100 mL of 10% LMD (dextran 40) in 0.9% Sodium Chloride Injection contains 10 g dextran40 and 0.9 g sodium chloride in water for injection. Total osmolar concentration is 310 mOsmol/liter(calc.); pH is 4.9 (3.5 to 7.0) (may contain sodium hydroxide and/or hydrochloric acid for pH adjustment).Electrolyte concentration per liter: Na 154 mEq; Cl ? 154 mEq (not including ions for pH adjustment).The solutions contain no bacteriostat, antimicrobial agent or added bufers (except for pH adjustment)and are intended only for single-dose injection. When smaller doses are required the unused portionshould be discarded.10% LMD (dextran 40) is an artificial colloid pharmacologically classified as a plasma volumeexpander; 5% Dextrose Injection isa fluid and nutrient replenisher; 0.9% Sodium Chloride Injection is aluid and electrolyte replenisher.Dextran 40 is a linear glucose polymer (polysaccharide) chemically 

右旋糖酐 Dextran 40 

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